Liver disease (including cirrhosis)Use with caution. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. ACE inhibitor-induced cough is not related to angioedema. ACE-inhibitors like lisinopril commonly cause a drug cough, and switching to an ARB due to this is fairly common. Your doctor may prescribe losartan if you've tried taking similar blood pressure-lowering medicines such as ramipril and lisinopril, but had to stop because of side effects such as a . Many patients who have high blood pressure will not notice any signs of the problem. Philip R. Cohen, MD (144-8), From the October 01, 2010 Issue of Clinical Advisor, Continuing Medical Education (CME/CE) Courses. I was told that I had an allergic reaction to penicillin when I was a child. Within the last year I have developed most of the rare conditions. Using this medicine with any of the following medicines is not recommended. View more, Losartan works on a hormone called angiotensin II to lower blood pressure and may also improve kidney function in some people. Both drugs have similar side effects, although lisinopril is more likely to cause a dry cough and has a risk of angioedema (severe allergic reaction). Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. This medicine may affect blood sugar levels. Difference Between Lisinopril And Losartan, Switching Between Losartan And Lisinopril. If it continues for a long time, the heart and arteries may not function properly. Where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, emergency treatment is necessary. Is loratadine-d & phenylephrine hcl safe together? Along with its needed effects, a medicine may cause some unwanted effects. Doing so increases the risk of low blood pressure, high potassium, and injury to the kidneys, which could be very serious or even potentially fatal. Do not use salt substitutes or potassium supplements while taking lisinopril, unless your doctor has told you to. However, the dose is usually not more than 0.61 mg per kg of body weight or 40 mg per day. If you notice any other effects, check with your healthcare professional. High blood pressure adds to the workload of the heart and arteries. Drinking alcohol while taking losartan or lisinopril can increase dizziness, or affect your blood pressure or other medical condition(s). Try the SingleCare prescription discount card. Consult a healthcare professional for a complete list of side effects. Studies have shown ARBs like losartan and ACE inhibitors like lisinopril to have similar effects. A summary of previous studies noted that angioedema recurrence in patients taking an ARB who previously had ACE inhibitor-induced angioedema varies from very low to as high as 50%. Hence, although the incidence of ARB-induced angioedema is low, it can still occur and can be potentially life-threatening (J Clin Hypertens [Greenwich]. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Switching from lisinopril to losartan may help reduce the likelihood of developing a dry cough. As a result, losartan relaxes the blood vessels. He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! It works quite well for most people. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine. Be sure to contact your doctor just to be sure you don't have any contraindications with lisinopril. All rights reserved. This blocks the effects listed above (e.g. For these, please consult a doctor (virtually or in person). No warnings were found for your selected drugs. Be sure to speak with your doctor regarding whether or not they recommend you to switch to lisinopril temporarily. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. the dose you were taking, kidney function, other contraindications) and they have your complete medical history. Opens in a new tab or window, Visit us on Twitter. Minimally clinically significant. Would you consider a trial of an angiotensin II receptor blocker (ARB) in a patient who has an ACE inhibitor allergy? When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. With a SingleCare coupon, the price range is $9-$16 depending on the participating pharmacy. Do not use supplements or salt substitutes containing potassium without first checking with your doctor. Losartan can be used in people 6 years of age and older. You shouldn't switch between losartan and lisinopril without first talking to your doctor. Angiotensin II narrows the blood vessels and increases blood pressure, so by blocking the production of angiotensin II, blood pressure is lowered. Read and follow the instructions carefully. This can cause high levels of potassium in your blood. Consult your doctor about the use of alcohol with losartan or lisinopril. However, the dose is usually not more than 40 mg per day. This is a decision you and your doctor will make. Consult your healthcare professional for a full list of side effects. Other warnings that apply to losartan and lisinopril: Losartan is an angiotensin receptor blocker that helps lower blood pressure. People with a type of heart disease called hypertrophic obstructive cardiomyopathy. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Hyperkalemia may also be associated with poor renal function and a serum creatinine test may be warranted to assess your kidney function. Children 6 years of age and olderDose is based on body weight and must be determined by your doctor. This includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. See below for a general idea of equivalent doses between losartan and lisinopril for high blood pressure: Dosage adjustment only if volume-depleted. Inomata N. Recent advances in drug-induced angioede-ma. Diabetes patients who are also taking aliskiren (Tekturna) or. Use an effective form of birth control to keep from getting pregnant. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium. Genetic disorders, such as C1 esterase inhibitor protein deficiency, and seasonal allergies are also risk factors for the development of angioedema.14,15 The common cellular mechanism among these causes appears to be activation of the complement system and/or other pro-inflammatory cytokines such as prostaglandins and histamine, which can result Staff. Alcohol may make the low blood pressure effect worse or increase the possibility of dizziness or fainting. Electrolyte imbalances (eg, high or low potassium or sodium in the body)Use with caution. Please login or register first to view this content. In our latest question and answer, the pharmacist discusses switching between two blood pressure medications, losartan and lisinopril. Do not take other medicines unless they have been discussed with your doctor. This typically happens within the first week of treatment, but rarely occurs later in therapy. My doctor switched me from an ACE inhibitor to Entresto yesterday. Many patients who have high blood pressure will not notice any signs of the problem. We comply with the HONcode standard for trustworthy health information. Lisinopril belongs to the classification of drugs called ACE (angiotensin-converting enzyme) inhibitors, while losartan is in the ARB (angiotensin II receptor-blocker) class. Opens in a new tab or window, Visit us on Instagram. Avoid alcoholic beverages until you have discussed their use with your doctor. The amount of medicine that you take depends on the strength of the medicine. Votes: +1 GO Gordon1960 25 July 2018 Losartan has an average rating of 4.5 out of 10 from a total of 540 ratings on Drugs.com. In both cases, patients had seasonal allergies and were found to have immunoglobulin E (IgE) sensitization to birch. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Losartan or lisinopril should not be used in combination with another ACE inhibitor, ARB, or Tekturna (aliskiren) because the combination increases the risk of low blood pressure, high potassium, fainting, kidney damage, or kidney failure. The presence of other medical problems may affect the use of this medicine. High blood pressure adds to the workload of the heart and arteries. It will be Monday or Tues before they give me any. Both ACE inhibitors and ARBs are known to increase the risk of having hyperkalemia, or high potassium. have ever had an allergic reaction to lisinopril or any other medicine are trying to get pregnant, are already pregnant or breastfeeding are having dialysis or any other type of blood filtration have heart, liver or kidney problems have unstable or low blood pressure have diabetes Losartan is an angiotensin II receptor blocker (ARB). May make these conditions worse. One patient on lisinopril (Prinivil, Zestril . This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. This is a decision you and your doctor will make. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. 26% of reviewers reported a positive effect, while 48% reported a negative effect. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Angiotensin-converting enzyme (ACE) inhibitors are the leading cause of drug-induced angioedema in the United States because they are so widely prescribed. As such, reducing angiotensin II produces vasodilation (among other effects), which reduces blood pressure. Examples include captopril (Capoten), enalapril (Vasotec), and lisinopril (Prinivil). Diabetic Kidney Disease (Diabetic Nephropathy). However, safety and efficacy have not been established in children younger than 6 years of age. This reaction can occur anytime during treatment. Although some blood pressure medications are used in combination (such as losartan or lisinopril in combination with a diuretic), lisinopril and losartan should not be taken together. I am currently on a daily dose of Losartan, which is working very well. Along with its needed effects, a medicine may cause some unwanted effects. No information is available on the relationship of age to the effects of losartan to treat other indications in the pediatric population. It works by blocking a substance in the body that causes blood vessels to tighten. Losartan is an angiotensin receptor blocker. A second patient on the same drug for a year developed tongue angioedema three times after eating jackfruit and cashews, the researchers reported in a poster presentation here at the American College of Allergy, Asthma, and Immunology meeting. Commonly reported side effects include: See also: lisinopril side effects in more detail. Both losartan and lisinopril are covered by insurance and Medicare Part D in the generic form.