-, Drago F, Ciccarese G, Javor S, Parodi A. Vaccineinduced pityriasis rosea and pityriasis rosealike eruptions: a review of the literature. Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. Inverse pityriasis rosea secondary to COVID-19 vaccination. Keywords: The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. doi: 10.1007/s10103-019-02783-8, 16. Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. doi: 10.1016/j.jdcr.2018.04.002, 12. (a) haematoxylineosin, original magnification 10. A virus may cause pityriasis rosea, but experts aren't sure. JAAD Int. HHS Vulnerability Disclosure, Help I tell my patient to use a gentle non-soap cleanser." Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. Those ensuing spots like the circle of dots that erupted on my back a day after the initial raised welt appeared typically resemble a Christmas tree-like formation. The ones found in people with pityriasis rosea are human herpesviruses 6 and 7. "And it has a particular [dermatomal] distribution because it's along a nerve," which also presents as fluid-filled blisters, rather than lesions. A spectrum of cutaneous reactions to SARs-CoV-2 (COVID-19) vaccines have been reported in the literature. Of the reported cases, 96.7% were secondary to the Pfizer vaccine, with only 1 reported . 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. The appearance of pityriasis rosea following the first injection of the AstraZeneca vector vaccine suggests a causal connection. The exanthem was self-limited in both patients over a period of a month. Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of COVID19. Physical examination revealed that lesions were distributed along cleavage lines, similar to PR, without herald patch or prominent scales (Figure 1C). doi: 10.7759/cureus.27108. Pearls and pitfalls: Adverse cutaneous reactions after COVID-19 vaccination. It looked like one, and it certainly itched like one but then more came. 2021;35(8):e489e491. Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. Advertising on our site helps support our mission. It should clear your body in six to eight weeks. HHS Vulnerability Disclosure, Help J Eur Acad Dermatol Venereol. An official website of the United States government. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. It is important for physicians to be aware of this self-limited reaction so they can reassure and appropriately counsel patients that it is safe to receive subsequent vaccine doses despite the cutaneous eruption. We do not endorse non-Cleveland Clinic products or services. Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational study. Int J Dermatol. 2021 May;62(2):e333-e334. Int J Infect Dis. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. In approximately 50% of people with pityriasis rosea, the patches itch. This Month in JAAD International: August 2022: Cutaneous reactions to COVID-19 messenger RNA booster dose vaccination. 6 Called a "herald patch,". Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. The patient presented to the Department of Dermatology for a 3 week duration of an extremely pruritic erythematous-squamous lesion, initially on the trunk and upper limbs, with extension to the lower limbs in the last week and the lesion respected the cephalic extremity, palms, and soles. Studies show that the development of pityriasis rosea during pregnancy may cause birth complications, including miscarriage and poor muscle tone and development once the baby is born (neonatal hypotonia). Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Even though it is benign, it can cause substantial. Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements. An official website of the United States government. The papillary dermis shows melanin incontinence, perivascular lymphocytic infiltrate and rare scattered extravasated red blood cells. Clinical findings of pityriasis rosealike eruption in the patients. The site is secure. J Med Virol. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage, Herald patch of pityriasis rosea. FOIA Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. For most people, it resolves without treatment. 1. Unauthorized use of these marks is strictly prohibited. Among the common cutaneous manifestations of COVID-19 (e.g., morbilliform eruptions, chilblains, and varicella-like vesicles), PR and PR-like eruptions have rarely been described (6, 7). doi: 10.1111/dth.13730. We present two cases of COVID-19 vaccine-induced pityriasis rosea. The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s. 2022 Mar 9;35(3):342-343. doi: 10.1080/08998280.2022.2044742. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Generalized Papulovesicular Eruption as a Side Effect of the Pfizer-BioNTech COVID-19 Vaccine. Appointments 216.444.5725 Appointments & Locations Request an Appointment In addition to a corticosteroid cream, New York City-based dermatologist Macrene Alexiades recommends keeping showers short and lukewarm, as "water, sweat, and soap reportedly irritate and inflame the lesions. However, there isnt enough research to determine that stress may cause pityriasis rosea. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Disseminated erythematous-papulosquamous lesions, with right. Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. The average time between vaccination and rash onset is 10 days, and most patients experience pruritus (70%). Though pityriasis rosea is a common skin rash, it can still make you feel self-conscious, and it can be unpleasant if it itches. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Accessibility Authors Lina Abdullah 1 Indian J Dermatol 2016;61:37584. Bethesda, MD 20894, Web Policies Luckily, it's not contagious. An official website of the United States government. NCI CPTC Antibody Characterization Program. PMC (2020) 33:e13650. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This site needs JavaScript to work properly. (c) Patient 2: Thin red to tan oval plaques with peripheral scale on the trunk and proximal thigh. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Bookshelf Unable to load your collection due to an error, Unable to load your delegates due to an error. We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. and transmitted securely. Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Before Is there a prescription cream or ointment that you can prescribe? Adverse cutaneous reactions following COVID-19 vaccines have increased, highlighting not only how SARS-CoV-2 infection but also COVID-19 vaccines may induce adverse cutaneous manifestations. FOIA If you have pityriasis rosea, its unlikely that youll get it again. The etiopathogenesis of PR is still unknown, but is frequently associated with episodes of upper respiratory tract infections. You may initially develop a fever, headache or upper respiratory infection. Some research shows that people who follow a Mediterranean diet have lower levels of inflammation in their bodies. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. 2021 Aug;185(2):e34. COVID-19-associated pityriasis rosea in children: Case report and literature review. FOIA Clinical aspect of the lesions after 7 days of treatment. Unauthorized use of these marks is strictly prohibited. 7 Articles, This article is part of the Research Topic, Creative Commons Attribution License (CC BY), Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. official website and that any information you provide is encrypted -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. Although the exact pathogenesis of PR remains unknown, the endogenous systemic reactivation of HHV (i.e., type 6 and 7) in the skin has been implicated as a precipitating factor. Epub 2022 Jun 21. Published by Wolters Kluwer Health, Inc. doi: 10.12998/wjcc.v5.i6.203, 6. Before Bin Rubaian NF, Almuhaidib SR, Aljarri SA, Alamri AS. FOIA Contact your healthcare provider as soon as you notice a rash. official website and that any information you provide is encrypted Medicines (Basel). COVID-19; Vaccination; pityriasis rosea. Epub 2020 Nov 20. The site is secure. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Anyone can get pityriasis rosea. Pityriasis rosea is also known as Christmas tree rash. Unable to load your collection due to an error, Unable to load your delegates due to an error. Pityriasis rosea following SARS-CoV-2 vaccination: A case series.